Confirmed speakers

Varinder Aggarwal, University of Bristol (UK)


Assembly Line Synthesis

Nature has evolved highly sophisticated machinery for organic synthesis, many of which resemble molecular assembly-line processes. So far chemists have been able to apply this type of approach in the synthesis of peptides and oligonucleotides but in these reactions, simple amide (C‒N) or phosphate (P‒O) bonds are created. It is much more difficult to make C‒C bonds but this is central to the discipline of organic synthesis. This difficulty is why organic synthesis is challenging and why robust, iterative or automated methodologies have not yet emerged.
Here, we describe the application of iterative homologation of boronic esters using chiral lithiated carbamates and chloromethyllithium enabling us to grow carbon chains with control over both relative and absolute stereochemistry. Application of this strategy to the synthesis of the proposed structure of baulamycin and the real structure will be presented as well as other complex targets. In addition, the methodology is used to answer fundamental questions about nature and the specific role of methyl substituents in carbon chains. By understanding their role, I will show that molecules can be created with linear or helical conformations or hybrids of the two.

Serena Arnaboldi, Università degli Studi di Milano (IT)


Redox Chemistry On-the-Fly for Enantioselective Synthesis

Chemistry on-the-fly is an interesting concept, extensively studied in recent years due to its potential use for recognition, quantification and conversion of chemical species in solution. In this context, chemistry on-the-fly for asymmetric synthesis is a promising field of research, since it can help to overcome mass transport limitations, present for example in conventional organic electrosynthesis. Furthermore the synergy between a magnetic field-enhanced self-electrophoretic propulsion mechanism and enantioselective redox chemistry on-the-fly can boost the stereoselective conversion. In this light, some examples will be proposed in which both reaction yield and conversion rate will be improved compared to the static approaches.

Giorgio Bencivenni, Università degli Studi di Bologna (IT)


Recent Advances in the Enantioselective Synthesis of Axially Chiral Compounds

Chiral compounds containing stereogenic axis have been considered in the past a laboratory curiosity with rare known examples of applications in asymmetric synthesis. Things have changed very quickly in the last twenty years when the important role and the enormous impact that this class of chiral substrates have in medicinal, biological and material chemistry were demonstrate. In my talk I will focuse on the recent advances in the enantioselective synthesis of axially chiral compounds highlighting the strategies and breakthroughs to address this synthetic challenge and their impact on both academic research field and industrial applications.

Davide Faccialà, Institute for Photonics and Nanotechnologies - CNR (IT)


Measuring Ultrafast Chiral Dynamics in Molecules with Atomic Site Selectivity

Fuchter Matthew, Imperial College London (UK)


Maximising Dissymmetry and Handling Directionality in Chiral Materials

We have an ongoing interest in the development of conjugated chiral molecules which can emit and detect circularly-polarised (CP) light within thin film materials and in organic electronic devices. CP light is central to many applications, including data storage, quantum computation, biosensing, environmental monitoring and display technologies. Such technologies require the generation of device compatible materials. Using a range of chiral materials - helicenes, fullerenes and polymers - this talk will give an overview of our strategies to maximise the selectivity of such chiral-optical responses through molecular design, materials processing and device architecture.

Caroline Paul, Delft University of Technology (NL)


Biocatalysis with flavoenzymes for asymmetric synthesis

Ivo Starý, IOCB Prague, Czech Academy of Sciences (CZ)


Helically Chiral Aromatics: From Synthesis to Applications

Helically chiral aromatics have recently attracted considerable attention, which has led to tremendous progress in their synthesis and, hand in hand with this, to intriguing applications. Advances in selected areas of helicene chemistry and physics will be discussed, including privileged synthetic methodologies, application in asymmetric transition metal catalysis, single-molecule charge transport, CPL emission along with other properties of complex helicene architectures